Biomarker discovery in mass spectrometry-based urinary proteomics
نویسندگان
چکیده
منابع مشابه
Proteomics and Mass Spectrometry for Cancer Biomarker Discovery
Proteomics is a rapidly advancing field not only in the field of biology but also in translational cancer research. In recent years, mass spectrometry and associated technologies have been explored to identify proteins or a set of proteins specific to a given disease, for the purpose of disease detection and diagnosis. Such biomarkers are being investigated in samples including cells, tissues, ...
متن کاملMass spectrometry-assisted gel-based proteomics in cancer biomarker discovery: approaches and application
There is a critical need for the discovery of novel biomarkers for early detection and targeted therapy of cancer, a major cause of deaths worldwide. In this respect, proteomic technologies, such as mass spectrometry (MS), enable the identification of pathologically significant proteins in various types of samples. MS is capable of high-throughput profiling of complex biological samples includi...
متن کاملMass spectrometry-based proteomics and peptidomics for biomarker discovery in neurodegenerative diseases.
There is an urgent need to search for biomarkers that are indicative of neurodegenerative diseases, as the clinical diagnosis of which remains unsatisfactory. Mass spectrometry (MS) has been playing an important role in studying peptide and protein identities, structures, modifications and interactions that collectively drive their biological functions. MS-based proteomics technology is thus we...
متن کاملMass spectrometry based translational proteomics for biomarker discovery and application in colorectal cancer.
Colorectal cancer (CRC) is a leading cause of cancer-related death in the world. Clinically, early detection of the disease is the most effective approach to tackle this tough challenge. Discovery and development of reliable and effective diagnostic tools for the assessment of prognosis and prediction of response to drug therapy are urgently needed for personalized therapies and better treatmen...
متن کاملLabel-free mass spectrometry-based proteomics for biomarker discovery and validation.
For most diseases, better biomarkers are urgently needed to enable (early) detection, diagnosis, prognosis, stratification for therapy and response monitoring. Proteomics delineates gene products that carry out the majority of cellular functions, and thereby may not only yield insight into altered signaling pathways in disease, but also yield novel biomarkers. In recent years, great progress ha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PROTEOMICS - Clinical Applications
سال: 2016
ISSN: 1862-8346
DOI: 10.1002/prca.201500102